Akhmetshina, A., Bianco, V., Bradić, I., Korbelius, M., Pirchheim, A., Kuentzel, K. B., Eichmann, T. O., Hinteregger, H., Kolb, D., Habisch, H., Liesinger, L., Madl, T., Sattler, W., Radović, B., Sedej, S., Birner-Grünberger, R., Vujić, N., & Kratky, D. (2024). Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice. Molecular Metabolism, 79, Article 101869. https://doi.org/10.1016/j.molmet.2023.101869
Energy metabolism; LAL; LAL deficiency; Lal-deficient mouse; Muscle proteomics
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Abstract:
Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an important role in SM development, function, and metabolism as a result of lipid and/or carbohydrate metabolism disruptions.
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Project title:
Lipidhydrolyse im Krebs und in Lipid-assoziierten Krankheiten: F 7309-B21 (FWF - Österr. Wissenschaftsfonds)
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Project (external):
Austrian Science Fund (FWF) Austrian Research Promotion Agency (FFG)
CC BY 4.0
