Hantzsch esters as formylation agents under photochemical conditions

Abstract

Photoreactions have gained prominence due to their ability to operate under mild conditions, aligning with the principles of green chemistry. Hantzsch esters have emerged as noteworthy compounds as hydrogen donors in transfer reactions. In recent developments, excited Hantzsch esters have been recognized as potent reductants, opening new avenues for the application in radical reactions and expanding their role as efficient radical reservoirs for late-stage functionalization. This thesis focuses on the formation of acetals from activated olefins employing Hantzsch esters both as reducing agents and acetal reservoirs. This approach not only aligns with the principles of green chemistry but also expands the repertoire of strategies for late-stage functionalization. Investigations into different parameters were undertaken to determine the optimal reaction conditions, leading to an expanded scope that encompasses a variety of olefins. The newly established system exhibited consistently high yields across a broad range of substrates.