Papaplioura, E., Mercier, M., Muratore, M. E., Biberger, T., Jerhaoui, S., & Schnürch, M. (2024). Tetraethylammonium Salts as Solid, Easy to Handle Ethylene Precursors and Their Application in Mizoroki-Heck Coupling. Journal of Organic Chemistry, 89(7), 5126–5133. https://doi.org/10.1021/acs.joc.3c02867
Heck coupling; ethylene; Chemical reactions; Mixtures
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Abstract:
In this study, we introduce a convenient Heck vinylation protocol that eliminates the requirement for ethylene gas as a coupling partner. In contrast to traditional methodologies, quaternary ammonium salts can serve as solid olefin precursors under ambient atmosphere conditions. The practicality of this method, distinguished by its convenience and safety in a one-pot reaction, renders it appealing for applications in research and discovery context.
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Research facilities:
Zentrum für Kernspinresonanzspektroskopie
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Project title:
C-H Activation Towards Industrial Renewal: 860762 (European Commission)
CC BY 4.0
