As data volumes are growing faster than the computing power, the computer science community is forced to look for alternatives beyond von Neumann architecture. Among different architectures that are currently being developed, Quantum Computing is one of the most promising ones. In this talk we discuss the concept of hybrid Classic-Quantum architecture and challenges when executing an application on a hybrid computational continuum where parts of the application are executed on the classic machine and parts of the application are executed on the quantum machine. We discuss the problems and challenges caused by the complexities of noise, hyperparameter optimization and data encoding.