Schmidbauer, A., Baltzaki, M. C. I., Markovic, M., Slezak, P., Redl, H., & Baudis, S. (2024). Human Platelet Lysate-functionalized Hydrogels as an Innovative approach for Bone Regeneration. In 2nd TCH Science Days PhD & Postdoc Day : Book of Abstracts (pp. 22–22). https://doi.org/10.34726/8683
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie E308-02-3 - Forschungsgruppe 3D Printing and Biofabrication E056-03 - Fachbereich BIOINTERFACE - Frontier Research in Nanotechnology and the Life Sciences E056-12 - Fachbereich ENROL DP E057-17 - Fachbereich Cell Culture Core Facility (CCCF)
-
Erschienen in:
2nd TCH Science Days PhD & Postdoc Day : Book of Abstracts
The potential for our bones to regenerate is greatly challenged by critical size bone defects, which also have a significant impact on the healing process and the functional outcome. To address these issues, bone implants are frequently utilized. The increased size of artificial scaffolds make it more difficult for biological components, vital nutrients, and cell ingrowth to be transported during the bio-integration stage.[1]
In this study, bio-interactive hydrogels which can potentially improve osseointegration of 3D-printed bone substitute scaffolds were developed. Human Platelet Lysate (PL) has cell-instructive and regenerative potential regarding bone regeneration and wound healing, Human Platelet Lysate (PL). In general, PL shows relatively weak mechanical properties, so we aimed for photopolymerizable derivatives.
Herein the successful novel modification of PL with allyl glycidyl ether (PLAGE) is reported. A variety of photocrosslinkable PL alternatives were synthesized and crosslinked, thereby improving the mechanical properties of the unmodified PL. Noteworthy, the formation of hydrogels was detected even without a thiol, suggesting that thiols in the PL backbone support gelation. Thorough characterization of the synthesized hydrogels via photorheology, swelling studies and preliminary in vitro experiments revealed promising results compared to literature-known relevant materials.[2] An in vivo preliminary test was conducted to investigate the degradation and inflammation grade of the most promising PL-based hydrogels. PL-derivatives present a promising new material platform for applications in the regenerative field.
en
Projekttitel:
Christian Doppler Labor für Fortschrittliche Polymere für Biomaterialien und den 3D Druck: CDL Baudis (Christian Doppler Forschungsgesells)
-
Projekt (extern):
Bundesministerium für Digitalisierung und Wirtschaftsstandort Nationalstiftung für Forschung, Technologie und Entwicklung