A versatile solvent-free Wittig olefination of sugars via mechanochemistry is reported, tolerating common protecting groups as well as unprotected substrates. The method efficiently delivers structurally diverse olefins under mild and solvent-free conditions. Subsequent solvent-free late-stage modifications of the olefins demonstrate the potential of the methodology for greener sugar-based synthetic sequences.
en
Research facilities:
Zentrum für Kernspinresonanzspektroskopie
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Project title:
Substitution von gasförmigen Reagenzien durch Feststoffe: P 33064-N (FWF - Österr. Wissenschaftsfonds)
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Research Areas:
Sustainable Production and Technologies: 50% Efficient Utilisation of Material Resources: 50%
CC BY 4.0
