In recent years, mechanochemical organic synthesis has gained more and more interest in the community and emerged from the role of a niche application to a more widely applied method. This is promoted by factors such as the aim to reduce waste in chemical synthesis, where solvents are the biggest contributor, and also due to increasing restrictions for the use of established organic solvents. Hence, establishing fundamental organic reactions under solvent free conditions is imperative. Along this line, we report on a set of such transformations including Tsuji-Trost allylations, Wittig reactions, C(sp3)-H functionalization, and Diels-Alder reactions (unpublished). Furthermore, it will be demonstrated, that these transformations can be incorporated in multistep reaction sequences without isolation of intermediate products. Most importantly, it will be shown, that the methods are applicable to compounds of relevance as active pharmaceutical ingredients.