Record link: 
http://hdl.handle.net/20.500.12708/224669
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Title: 
Investigating the bioorthogonality of isocyanides
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Citation: 
Nakao, R., Savic, V., Miles, J. A., Livingstone, K., Mihovilovic, M. D., Raubo, P., Warriner, S. L., & Wright, M. H. (2026). Investigating the bioorthogonality of isocyanides. Chemical Communications. https://doi.org/10.1039/d5cc04136h
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Publisher DOI: 
10.1039/d5cc04136h
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Publication Type: 
Article - Original Research Article
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Language: 
English
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Authors: 
Nakao, Ryota 
Savic, Viktor 
Miles, Jennifer A 
Livingstone, Keith 
Mihovilovic, Marko D. 
Raubo, Piotr 
Warriner, Stuart L 
Wright, Megan H 
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Organisational Unit: 
E163-03-4 - Forschungsgruppe Bioorganische Synthesechemie 
E056-12 - Fachbereich ENROL DP 
E056-24 - Fachbereich GreenChem-TechHub 
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Journal: 
Chemical Communications 
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ISSN: 
1359-7345
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Date (published): 
2026
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Number of Pages: 
5
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Publisher: 
ROYAL SOC CHEMISTRY
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Peer reviewed: 
Yes
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Keywords: 
Bioorthogonal Chemistry; Isocyanides
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Abstract: 
Isocyanides have been applied in bioorthogonal reactions as triggers for uncaging reactions. However, emerging evidence suggests that they may label proteins covalently. We synthesised a fluorophore-conjugated isocyanide and analysed its protein reactivity. Our results suggest that isocyanides cannot be considered to be bioorthogonal in chemical biology.
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Project title: 
Doktoratskolleg W 1232-B11: DK W1232-B11 (FWF - Österr. Wissenschaftsfonds) 
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Research Areas: 
Beyond TUW-research focus: 100%
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Science Branch: 
1040 - Chemie: 60%
2040 - Chemische Verfahrenstechnik: 20%
3012 - Pharmazie, Pharmakologie, Toxikologie: 20%
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