Sajedi, S. S. (2018). Intra- and extracellular stimulation of spiking bipolar cells on macaque’s retina [Diploma Thesis, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2018.51201
This study aims to investigate the behaviour of an ON (cone) diuse bipolar cell DB4 of the macaque retina with intra and extra-stimulations applied and recorded in dierent parts of the cell. The simulation of the cell is achieved by applying the Hodgkin-Huxley multi-compartment model and employing the Backward Euler solver through Python (Version 2.7). In the end, a channel noise is added to compute more realistic responses and has been compared with the previous results. Results of the intracellular stimulation show how the electrode position and the waveform is essential in order to get a proper response from the cell. A rectangular pulse is found stronger than a sinusoidal pulse with the same amplitude of 50 pA. The electrode position in sodium band and terminal caused stronger responses in contrast to soma and dendrite. Most spikes are found in frequencies between 20 to 60 HZ.
