Title: New synthesis pathways for a ß-lactamase inhibitor
Language: English
Authors: Himmelbauer, Daniel 
Qualification level: Diploma
Keywords: Antibiotics; beta-Lactamase Inhibitor; Avibactam; Synthesis
Advisor: Gärtner, Peter  
Issue Date: 2016
Number of Pages: 72
Qualification level: Diploma
Abstract: 
Bacterial strains came under enormous pressure due the overuse of ß-lactam antibiotics. In a selective process only the resistant strains survived and new ß-lactamase resistances were formed. Avibactam is the first non-ß-lactam ß-lactamase inhibitor which is used clinically since more than 20 years. Compared to its predecessors it has unique properties and a wider scope of activity against ß-lactamases. By developing a new synthetic route for avibactam, the originator process patent can be circumvented and it is possible to be the first generic company on the market.
URI: https://resolver.obvsg.at/urn:nbn:at:at-ubtuw:1-127572
http://hdl.handle.net/20.500.12708/5965
Library ID: AC13319399
Organisation: E163 - Institut für Angewandte Synthesechemie 
Publication Type: Thesis
Hochschulschrift
Appears in Collections:Thesis

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