Title: FTIR spectroscopy as a novel analytical approach for investigation of glucose transport and glucose transport inhibition studies in transwell in vitro barrier models
Language: English
Authors: Rothbauer, Mario 
Eilenberger, Christoph
Spitz, Sarah 
Bachmann, Barbara 
Pajenda, Jasmin 
Schwaighofer, Andreas  
Höll, Gregor 
Helmke, Palle Steen 
Kohl, Yvonne 
Lendl, Bernhard  
Ertl, Peter  
Category: Short/Brief/Rapid Communication
Short/Brief/Rapid Communication
Issue Date: 2020
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
ISSN: 1386-1425
Glucose transport is key for cellular metabolism as well as physiological function and is maintained via passive facilitated and active sodium-glucose linked transport routes. Here, we present for the first time Fouriertransform infrared spectroscopy as a novel approach for quantification ofapical-to-basolateral glucose transport ofin vitro cell barriermodels using liver, lung, intestinal and placental cancer cell lines. Results ofour comparative study revealed that distinct differences could be observed upon subjection to transport inhibitors.
Keywords: FITR; Cancer cell barriers; Transwell; Glucose transport; Transport inhibition
DOI: 10.1016/j.saa.2020.118388
Library ID: AC15639607
URN: urn:nbn:at:at-ubtuw:3-9901
Organisation: E164 - Institut für Chemische Technologien und Analytik 
Publication Type: Article
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