We describe the use of phenyl trimethylammonium iodide (PhMe3NI) as an alternative methylating agent for introducing a CH3group in α-position to a carbonyl group. Compared to conventional methylating agents, quaternary ammonium salts have the advantages of being nonvolatile, noncancerogenic, and easy-to-handle solids. This regioselective method is characterized by ease of operational setup, use of anisole as green solvent, and yields up to 85%.
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Research facilities:
Zentrum für Kernspinresonanzspektroskopie
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Project title:
Substitution von gasförmigen Reagenzien durch Feststoffe: P 33064-N (Fonds zur Förderung der wissenschaftlichen Forschung (FWF))