Title: Synthesis and Characterization of 17-Epistanozolol- N-Glucuronides for Anti-Doping Purposes
Other Titles: Synthesis and Characterization of 17-Epistanozolol- N-Glucuronides for Anti-Doping Purposes
Language: English
Authors: Stadler, Georg 
Qualification level: Diploma
Keywords: Stanozolol; steroids
Stanozolol; Steroids
Advisor: Gärtner, Peter  
Assisting Advisor: Enev, Valentin 
Issue Date: 2021
Number of Pages: 85
Qualification level: Diploma
The aim of this thesis was the synthesis of urinary metabolites of the anabolic androgenic steroid stanozolol for anti-doping purposes and comparison with human metabolic molecules. Focus was put on the synthesis of the in position 17 epimerized metabolite of stanozolol and the N glucuronides of this molecule. Synthesis of 17-epistanozolol was carried out starting from stanozolol via sulfation of the tertiary alcohol and hydrolysis under basic conditions. N Glucuronides of this product were synthesized through modified Koenigs-Knorr glycosylation conditions with mercury salts for activation. The obtained synthetic metabolites were deprotected under basic conditions, fully characterized and compared with human urinary metabolic products.
URI: https://doi.org/10.34726/hss.2021.86891
DOI: 10.34726/hss.2021.86891
Library ID: AC16123100
Organisation: E163 - Institut für Angewandte Synthesechemie 
Publication Type: Thesis
Appears in Collections:Thesis

Show full item record

Page view(s)

checked on Feb 27, 2021


checked on Feb 27, 2021

Google ScholarTM


Items in reposiTUm are protected by copyright, with all rights reserved, unless otherwise indicated.