Title: Synthesis and Characterization of 17-Epistanozolol- N-Glucuronides for Anti-Doping Purposes
Other Titles: Synthesis and Characterization of 17-Epistanozolol- N-Glucuronides for Anti-Doping Purposes
Language: English
Authors: Stadler, Georg 
Qualification level: Diploma
Advisor: Gärtner, Peter  
Assisting Advisor: Enev, Valentin 
Issue Date: 2021
Number of Pages: 85
Qualification level: Diploma
The aim of this thesis was the synthesis of urinary metabolites of the anabolic androgenic steroid stanozolol for anti-doping purposes and comparison with human metabolic molecules. Focus was put on the synthesis of the in position 17 epimerized metabolite of stanozolol and the N glucuronides of this molecule. Synthesis of 17-epistanozolol was carried out starting from stanozolol via sulfation of the tertiary alcohol and hydrolysis under basic conditions. N Glucuronides of this product were synthesized through modified Koenigs-Knorr glycosylation conditions with mercury salts for activation. The obtained synthetic metabolites were deprotected under basic conditions, fully characterized and compared with human urinary metabolic products.
Keywords: Stanozolol; steroids
Stanozolol; Steroids
URI: https://doi.org/10.34726/hss.2021.86891
DOI: 10.34726/hss.2021.86891
Library ID: AC16123100
Organisation: E163 - Institut für Angewandte Synthesechemie 
Publication Type: Thesis
Appears in Collections:Thesis

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