Record link: 
http://hdl.handle.net/20.500.12708/192095
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Title: 
Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of ¹⁸F-tetrazines
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Citation: 
Wilkovitsch, M., Svatunek, D., Mikula, H., & Denk, C. (2023). Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of 18F-tetrazines. MONATSHEFTE FUR CHEMIE, 154(12), 1441–1457. https://doi.org/10.1007/s00706-023-03140-w
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Publisher DOI: 
10.1007/s00706-023-03140-w
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Publication Type: 
Article - Original Research Article
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Language: 
English
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Authors: 
Wilkovitsch, Martin 
Svatunek, Dennis 
Mikula, Hannes 
Denk, Christoph 
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Organisational Unit: 
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie 
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Journal: 
MONATSHEFTE FUR CHEMIE 
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ISSN: 
0026-9247
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Date (published): 
15-Nov-2023
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Number of Pages: 
17
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Publisher: 
SPRINGER WIEN
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Peer reviewed: 
Yes
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Keywords: 
Bioorthogonal chemistry; Click chemistry; Cycloadditions; Heterocycles; Kinetics; Radiochemistry
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Abstract: 
Radiolabeled 1,2,4,5-tetrazines are powerful heterocyclic agents for bioorthogonal PET imaging due to their fast cycloaddition with trans-cyclooctenes. However, fluorine-18 radiolabeling of highly reactive tetrazines is often not feasible due to limited compound stability. We demonstrate that post-radiolabeling oxidation of thioether functionalities is a viable and transferable strategy to avoid these limitations, enabling the synthesis of highly reactive 18F-tetrazines.
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Research facilities: 
TRIGA Mark II-Nuklearreaktor 
Zentrum für Kernspinresonanzspektroskopie 
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Project title: 
In Vivo Klick für PET": Verbesserung der Diagnose in der klinischen Nanomedizin: 668532 (European Commission) 
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Research Areas: 
Beyond TUW-research foci: 100%
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Science Branch: 
1040 - Chemie: 100%
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