Schachamayr, D., Templ, J., Weil, M., Gärtner, P., & Enev, V. S. (2024). Construction of the Bicyclic Carbon Framework of Euphosalicin. Journal of Organic Chemistry, 89(14), 10239–10257. https://doi.org/10.1021/acs.joc.4c01147
Our studies toward the total synthesis of the natural product euphosalicin (1) are presented. Different approaches targeting key intermediates are described, the synthesis of which includes findings on asymmetric dihydroxylations and ring-closing enyne metatheses (RCEYM). Their connection allowed the isolation of highly advanced precursors for studies on macrocyclizations. Our efforts culminated in the preparation of the unique C11/C12 (Z) isomer of the C13 nor methyl skeleton of euphosalicin (1).
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Project title:
Totalsynthese des Jatrophane Diterpens Euphosalicin: P 31623-N28 (FWF - Österr. Wissenschaftsfonds)
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Research Areas:
Biological and Bioactive Materials: 30% Sustainable Production and Technologies: 40% Beyond TUW-research focus: 30%
CC BY 4.0
