Title: Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides
Language: English
Authors: Anschuber, Martin 
Pollice, Robert 
Schnürch, Michael  
Category: Original Research Article
Issue Date: 2018
Journal: Monatshefte für Chemie - Chemical Monthly
ISSN: 1434-4475
Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent.
Keywords: C–H activation; C–H functionalization; Directing group Catalysis
DOI: 10.1007/s00706-018-2305-9
Library ID: AC15502305
URN: urn:nbn:at:at-ubtuw:3-6589
Organisation: E163 - Institut für Angewandte Synthesechemie 
Publication Type: Article
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