Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides

Anschuber, Martin; Pollice, Robert; Schnürch, Michael

doi:10.1007/s00706-018-2305-9

Datensatz Zitierlink:

https://resolver.obvsg.at/urn:nbn:at:at-ubtuw:3-6589
http://hdl.handle.net/20.500.12708/278

Titel:

Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides

Zitat:

Anschuber, M., Pollice, R., & Schnürch, M. (2019). Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides. Monatshefte Für Chemie - Chemical Monthly. https://doi.org/10.1007/s00706-018-2305-9

Verlags-DOI:

10.1007/s00706-018-2305-9

CatalogPlus:

AC15502305

Publikationstyp:

Artikel - Forschungsartikel

Sprache:

Englisch

Autor_innen:

Anschuber, Martin
Pollice, Robert
Schnürch, Michael

Organisationseinheit:

E163 - Institut für Angewandte Synthesechemie

Zeitschrift:

Monatshefte für Chemie - Chemical Monthly

ISSN:

0026-9247

Datum (veröffentlicht):

Jan-2019

Verlag:

Springer

Peer Reviewed:

Keywords:

C–H activation; C–H functionalization; Directing group Catalysis

Abstract:

Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent.

Lizenz:

CC BY 4.0