Anschuber, M., Pollice, R., & Schnürch, M. (2019). Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides. Monatshefte Für Chemie - Chemical Monthly. https://doi.org/10.1007/s00706-018-2305-9
C–H activation; C–H functionalization; Directing group Catalysis
en
Abstract:
Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent.
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